B.Pharmacy Physical Pharmaceutics I
Explore the physicochemical principles that govern drug substances and dosage forms, with emphasis on solubility, states of matter, surface phenomena, complexation, protein binding, pH, buffers, and isotonic solutions.
Develop a strong understanding of how physicochemical properties influence drug behavior, formulation design, drug stability, and pharmaceutical dosage-form development. The subject connects fundamental physical pharmacy concepts with their practical applications in pharmaceutical formulation and evaluation.
Topics Covered
- Solubility of Drugs
- Solute–Solvent Interactions
- Ideal & Real Solutions
- Solvation & Association
- Factors Affecting Drug Solubility
- Diffusion in Biological Systems
- Raoult’s Law
- Critical Solution Temperature
- Distribution Law
- States of Matter
- Phase Changes & Latent Heat
- Vapour Pressure
- Sublimation
- Critical Point
- Eutectic Mixtures
- Gases & Aerosols
- Relative Humidity
- Liquid Crystals
- Glassy State
- Crystalline & Amorphous Forms
- Polymorphism
- Physicochemical Properties of Drug Molecules
- Refractive Index
- Optical Rotation
- Dielectric Constant
- Dipole Moment
- Dissociation Constant
- Surface & Interfacial Phenomena
- Surface & Interfacial Tension
- Surface Free Energy
- Spreading Coefficient
- Adsorption
- Surfactants
- HLB Scale
- Solubilization
- Detergency
- Complexation & Protein Binding
- Types of Complexes
- Methods of Analysis
- Applications of Complexation
- Drug–Protein Binding
- Complexation & Drug Action
- Thermodynamic Stability Constants
- pH
- Buffers & Isotonic Solutions
- Sorensen’s pH Scale
- pH Determination
- Buffer Equation
- Buffer Capacity
- Pharmaceutical & Biological Buffers
- Buffered Isotonic Solutions
What You’ll Get
✓ Exam-Focused Notes
✓ Structured Lecture Notes
✓ GPAT Preparation Material
✓ Physical Pharmacy & Formulation Concepts
✓ Pharmacy-Relevant Learning Resources
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