B.Pharmacy Medicinal Chemistry I
Explore the chemistry of medicines through drug classification, mechanisms of action, physicochemical properties, drug metabolism, structure–activity relationships (SAR), and the synthesis of important therapeutic agents.
Build a strong foundation in Medicinal Chemistry by understanding how the chemical structure of a drug influences its biological activity, pharmacological effects, metabolism, and therapeutic applications. The subject covers major drug classes acting on the autonomic and central nervous systems, with emphasis on SAR, mechanisms, and synthesis of important drugs.
Topics Covered
- Introduction to Medicinal Chemistry
- History & Development of Medicinal Chemistry
- Physicochemical Properties & Biological Action
- Ionization
- Solubility
- Partition Coefficient
- Hydrogen Bonding
- Protein Binding
- Chelation
- Bioisosterism
- Optical & Geometrical Isomerism
- Drug Metabolism
- Phase I Reactions
- Phase II Reactions
- Factors Affecting Drug Metabolism
- Stereochemical Aspects of Drug Metabolism
- Autonomic Nervous System
- Adrenergic Neurotransmitters
- Catecholamine Biosynthesis & Catabolism
- Alpha & Beta Adrenergic Receptors
- Sympathomimetic Agents
- Direct-Acting Agents
- Indirect-Acting Agents
- Mixed-Mechanism Agents
- SAR of Sympathomimetics
- Adrenergic Antagonists
- Alpha Adrenergic Blockers
- Beta Adrenergic Blockers
- SAR of Beta Blockers
- Cholinergic System
- Acetylcholine Biosynthesis & Catabolism
- Muscarinic & Nicotinic Receptors
- Parasympathomimetic Agents
- Direct-Acting Cholinergic Agents
- Cholinesterase Inhibitors
- Reversible & Irreversible Inhibitors
- Cholinesterase Reactivators
- Cholinergic Blocking Agents
- Solanaceous Alkaloids
- Synthetic Anticholinergic Agents
- SAR of Cholinolytic Agents
- Central Nervous System Drugs
- Sedatives & Hypnotics
- Benzodiazepines
- Barbiturates
- Miscellaneous Sedative-Hypnotics
- Antipsychotics
- Phenothiazines
- Phenothiazine Ring Analogues
- Butyrophenones
- Benzamides
- Anticonvulsants
- Hydantoins
- Oxazolidine Diones
- Succinimides
- Ureas & Monoacylureas
- Miscellaneous Anticonvulsants
- General Anesthetics
- Inhalational Anesthetics
- Ultra-Short-Acting Barbiturates
- Dissociative Anesthetics
- Analgesics & Anti-inflammatory Agents
- Morphine & Related Drugs
- SAR of Morphine Analogues
- Narcotic Antagonists
- Non-Narcotic Analgesics
- Anti-inflammatory Agents
What You’ll Get
✓ Exam-Focused Notes
✓ Structured Lecture Notes
✓ GPAT Preparation Material
✓ SAR & Drug Design Concepts
✓ Drug Classification & Mechanism-Based Learning
✓ Important Drug Synthesis & Chemical Structures
✓ Pharmacy-Relevant Learning Resources
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